“Background: Adult survivors of childhood cancer adhere po


“Background: Adult survivors of childhood cancer adhere poorly to recommended medical surveillance. We sought to identify modifiable factors that contribute to non-adherence.

Methods: Latent class LY2090314 clinical trial analysis categorized survivors (ages 18-52years) at risk of cardiac, breast, or bone late sequelae on the basis of their health-related concerns, fears, and motivation. These classifications were compared at two time points for self-reported adherence to recommended

echocardiography, mammography, and bone densitometry screening.

Results: Three classes (worried, collaborative, and self-controlling) characterized survivors in each of the three risk groups: cardiac (N=564; Bayesian information criterion [BIC]=10,824.66; Lo-Mendell-Rubin parametric likelihood

ratio test [LRMLRT] P=.002), breast (N=584; BIC=11,779.97; LRMLRT P<.001), and bone (N=613; BIC=11,773.56; LMRLRT P=.028). Only 9% of at-risk survivors in the self-controlling class reported undergoing bone density screening in 2005, compared with 17.2% in the collaborative class (P=.034). Thirteen percent of the self-controlling, 24% of collaborative (P=.025), and 34% of worried (P=.010) classes reported undergoing bone densitometry in 2009. Whereas 73% of at-risk survivors in the worried class reported having had an echocardiogram in 2009, only 57% of the collaborative (P=.040) and 43% of self-controlling (P<.001) classes did. In 2005 and 2009, respectively, fewer survivors in the

self-controlling class (37% and 53%) than in the collaborative Nutlin-3 inhibitor (51%, P=.038 and 70%, P=.01) and worried (58%, P=.002 and 69%, P=.025) classes selleckchem reported undergoing mammograms.

Conclusions: Modifiable intrapersonal characteristics associated with these three classes predict self-reported participation in medical surveillance. Continued observation and validation of these survivor profiles may inform tailored interventions to enhance survivors’ screening participation. Copyright (c) 2012 John Wiley & Sons, Ltd.”
“Introduction and objectives. Patients with chronic bifascicular block (BFB) can progress to advanced atrioventricular block (AVB), especially when syncope or a prolonged HV interval is present. It is possible that other variables could help identify patients who would benefit from prophylactic pacemaker implantation.

Methods. The study involved 263 consecutive BFB patients seen at a single center between 1998 and 2006. Clinical, electrocardiographic and electrophysiologic variables were analyzed to identify predictors of progression to significant AVB (i.e. second or third grade). Cardiac pacemakers were implanted in accordance with European Society of Cardiology guidelines. Pacemakers were programmed in the VVI mode with a minimum frequency of 40 beats/min. A pacemaker was required if there was significant AVB or a ventricular pacing percentage >10%.

Results.

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