Results: In close agreement with pathophysiological fundamentals, significant (p < 0.001) increases in R0, Rm, and Z4Hz, and reductions in C(dyn) (p this website < 0.003) were observed. S and Xm presented smaller modifications (p < 0.02).
All FOT parameters were significantly correlated with spirometric indices. Z4Hz was the most adequate parameter for clinical use (Se = 75%, Sp = 75%), followed by R0 and Rm. Conclusions: FOT parameters were consistent with the pathophysiology of sarcoidosis and were also able to detect the effects of this disease. Because the FOT is easy to perform, such a technique may represent an alternative and/or a complement to other conventional exams to help the clinical evaluations of sarcoidotic patients. Copyright (C) 2009 S. Karger AG, Basel”
“Purpose: To identify the frequency, levels and predictors of potential drug-drug interactions (pDDIs) in a pediatrics ward of a teaching hospital in Pakistan.
Methods:
Medication profiles of 400 pediatric patients were evaluated for pDDIs using Micromedex Drug-Reax (R) software. Logistic regression was used to identify association of pDDIs with hospital-stay, patient’s gender, and number of medications.
Results: In total, 86 interacting drug-combinations resulting in 260 pDDIs were identified. Overall, 25.8 % patients were exposed to at least one pDDI regardless of severity-type, 10.7 % to at least one major-pDDI, 15.2 % to at least one moderate-pDDI, and 12.5 % to at ACY-738 ic50 least one minor-pDDI. Of 260 pDDIs, most were of moderate severity (41.5 %) followed by minor (35.4 %) and major severity (21.9 Vactosertib manufacturer %); good (76.9 %) or fair (16.5 %) type of scientific evidence; and delayed onset (46.5 %). Some widespread major or moderate interactions included rifampin + pyrazinamide (14 cases), phenobarbital + diazepam (14), dexamethasone + rifampin (8), amikacin
+ furosemide (7), furosemide + captopril (7), dexamethasone + phenobarbital (6), phenobarbital + divalproex sodium (6), isoniazid + rifampin (5) amikacin + ibuprofen (5), digoxin + furosemide (4), and acetaminophen + phenytoin sodium (4). There was significant association of the occurrence of pDDIs with five or more prescribed medications (p < 0.001).
Conclusion: PDDIs are less prevalent in the pediatrics ward of the hospital studied. Most of the interactions were of moderate severity. Patients with increased number of prescribed medications were more exposed to these interactions.”
“Aim: There is controversy regarding the effect of obesity on the treatment and survival of ovarian cancer. This study examined the impact of obesity on the treatment and survival outcomes of epithelial ovarian cancer.
Methods: The medical records of patients undergoing surgery for epithelial ovarian cancer (EOC) between January 2000 and February 2010 were reviewed. Patient demographics, surgical outcomes, clinicopathological factors and survival were evaluated and compared according to the body mass index (BMI).