a. I.P. Pavlov; Medical Military Academy named after S.M.

Kirov Objective: To study frequency of postinfectious irritable bowel selleck inhibitor syndrome (PI-IBS) in the citizens of a megapolis by the example of Saint-Petersburg (Russian Federation) past acute intestine infections. Methods: Randomly chosen representatives of the working population of Saint-Petersburg were checked for signs of irritable bowel syndrome. The 247 people (152 males and 95 females) at age of 20–69 with acute intestine infections in the anamnesis during last 6 months were included into the research. The acute intestine infections were salmonellosis (49 cases), acute dysentery (65), acute gastroenteritis (51), enterocolitis (25) and acute gastreoenterocolitis (57) viral etiology. PLX4032 The irritable bowel syndrome was diagnosed and verified according to the Roman

criteria III (2006) by endoscopic and morphological examination. Biopsies were obtained from the intestine at endoscopic examination. Biopsies were placed in 10% formalin and routinely embedded in paraffin blocks, then cut and stained in each local canter. The stained slides were examined by pathologist using the updated classification. The Chromogranin, Synaptophysin, NSE were determined by immunohistochemical methods for neuroendocrine tumors exclusion. Results: 61 persons, i.e. 24.7% of the research participants, were diagnosed with postinfectious irritable bowel syndrome after one of acute intestine infections. The patients age was 20–47 years, middle age – 30, 2 years, 27 males and 34 females. These patients had the clinical picture of irritable bowel syndrome. The clinical picture of IBS-likely condition was characterized presence of pain or discomfort in the abdomen at all patients; stool disorders – at 55 persons:

medchemexpress diarrhea was observed at 23 patients, constipation – at 25 patients, unstable stool – at 7 patients; sensation of incomplete emptying intestine and meteorism was observed 44 and 29 patients accordingly. In the anamnesis the 24.6% examined (15 patients) had salmonellosis, 44.3% (27 patients) – acute dysentery, 6.6% (4 patients) – acute gastroenteritis, 9.8% (6 patients) – acute enterocolitis, 14.8% (9 patients) – acute gastreoenterocolitis. Conclusion: The problem of postinfectious irritable bowel syndrome is actual. After acute intestine infections IBS-likely symptoms prevalence among the working citizens of Saint-Petersburg are high. This peculiarity dictates necessity of careful inspection this category of patients, formations of interaction of the infectionist and gastroenterologist. Key Word(s): 1. EPIDEMIOLOGY; 2. POSTINFECTIOUS IBS; 3. intestine infections; 4.