Solid State Ion 2003, 165:139.CrossRef 10. Guillén C, Herrero J: Transparent conductive

ITO/Ag/ITO multilayer electrodes deposited by sputtering at room temperature. Opt Commun 2009, 282:574.CrossRef 11. Sun X, Huang H, Kwok H: On the initial growth of indium tin oxide on glass. Appl Phys Lett 1996, 68:2663.CrossRef 12. Kim DH, Park MR, Lee HJ, Lee GH: Thickness dependence of electrical properties of ITO film deposited on a plastic substrate by RF magnetron sputtering. Appl Surf Sci 2006, 253:409.CrossRef 13. Jeong JA, KiKim H: Low resistance and highly transparent ITO–Ag–ITO multilayer electrode using surface plasmon resonance of Ag layer for bulk-heterojunction organic solar cells. J Sol Energ Mat Sol C 1801, 2009:93. Competing interests The authors declare that they have no competing interests. Authors’ contributions ZQS and QPX prepared the films and tested the surface topography. X-ray Protein Tyrosine Kinase inhibitor diffraction was investigated by XPS and MCZ. The optical properties were measured by GH. The calculations were

carried out by ZQS who also wrote the manuscript. Besides, MCZ helped draft the manuscript. All authors read and approved the final manuscript.”
“Background The use of nanosized colloids offers exciting new opportunities for biomedical HM781-36B concentration applications as they have the potential to overcome significant limitations associated with therapeutic drugs (e.g., physical, chemical, or biochemical instability). In addition, encapsulation of pharmacologically active agents into such nanocarriers allows for spatial and temporal control of drug release, which can significantly improve clinical effects (e.g., controlled and targeted delivery) [1, 2]. Superparamagnetic Fe3O4 nanoparticles (SPIONs) are explored as novel drug delivery systems as their orientation within a magnetic field offers new opportunities Carbohydrate to manipulate accumulation and/or drug release in desired target tissues by an externally applied magnetic field

[3]. Similar to other biomedical applications of SPIONs, including magnetic resonance imaging, biosensing, and cell separation, clinical development critically depends on efficient magnetization and favorable pharmacokinetic properties that minimize clearance by the reticuloendothelial system. It is generally accepted that nanoparticles with hydrophilic surfaces and those less than 200 nm in diameter are compliant with these desired specifications [4, 5]. The large surface-to-volume ratio of small magnetic nanoparticles increases surface energy and, thus, enhancing particle aggregation. As a consequence, chemical reactivity decreases, magnetic properties deteriorate, and clearance within a biological system increases [6–9]. Particle stability in an aqueous vehicle can be augmented by electrostatic repulsion using charged surface coatings and/or surface-associated ions, including OH-, H3O+, or buffer ions [10].