, 1999 and Albert et al., 2007), these densities are both classified as high-ESWT. No

significant differences were found between the groups on pain at rest, pain during activity, the Constant Score or improvement at 3 months and 1-year follow-up. Hence, there is no evidence Lumacaftor datasheet for effectiveness of 0.78 vs 0.33 mJ/mm2 for non-calcific tendinopathy in the short- and the long-term. One low-quality RCT (Schmitt et al., 2002) (n = 40) compared high-ESWT to placebo for supraspinatus tendinosis. No significant between-group differences were found on pain in rest or activity, the Constant score or subjective improvement score after 1-year. There is no evidence for the effectiveness of high-ESWT compared to placebo in patients with supraspinatus tendinosis in the long-term. A high-quality study (Schmitt et al., 2001) (n = 40) compared low-ESWT to placebo for supraspinatus tendinosis. At 12 weeks follow-up no significant between-group differences Metformin manufacturer were found on pain in rest or activity, the Constant score, or improvement. There is no evidence for the effectiveness of low-ESWT compared

to placebo for supraspinatus tendinosis in the short-term. A high-quality RCT (Gross et al., 2002) (n = 30) compared low-ESWT (EFD: 0.11 mJ/mm2) to X-ray radiation treatment (6 × 0.5 Gy) for supraspinatus tendinosis. No significant between-group differences were found on pain during rest and activity, the Constant score, or subjective improvement at 12 and 52 weeks follow-up. There is no evidence for the effectiveness of EWT compared to radiotherapy in the short and

long-term. One high-quality study (Speed et al., 2002) (n = 74) compared medium- to low-ESWT for non-calcific RC-tendinosis. At 3 and 6 months follow-up, no significant between-group differences were found on night pain or the SPADI score. There is no evidence for the effectiveness of medium or low-ESWT when compared to each other in the short and mid-term. A low-quality RCT (Melegati et al., 2000) (n = 90) (n = 60) compared three treatment groups: medium-ESWT sequently followed by kinesitherapy (group B) versus only kinesitherapy (i.e. the following exercises: Codman, capsular stretching, isometric for the rotator and the deltoid muscles, and elastic resistance for the rotators, deltoid and trapezius muscles) second (group A) versus controls (postural hygiene and joint economy suggestions) (group C) for non-calcific SIS. After 80 days, significant differences on the Constant score were found: group B scored 27.95% and 80.41% better than groups A and C, respectively. There is limited evidence that medium-ESWT plus kinesitherapy is more effective than kinesitherapy only or controls for treating SIS in the short-term. ESWT has been suggested as a treatment alternative for calcific and non-calcific RC-tendinosis, which may decrease the need for surgery. We studied the evidence for effectiveness of this treatment.