, 2010 and Pan et al., 2010). A later role for Notch signaling in the inner ear sensory epithelia is in its more traditional role: lateral inhibition. When hair cells begin to develop from the sensory epithelium, they signal via Dll1/Jag2/Notch1 interactions to suppress hair cell differentiation in the adjacent cells and instead direct them to develop as support cells (Haddon et al., 1998). The Notch signal induces expression of Hes5, a downstream effector in the Notch pathway (Kageyama and Ohtsuka, 1999),

and the Hes5 likely represses Atoh1, the bHLH class transcription factor necessary for hair cell development. In this way the alternating rows of hair cells and support cells are set up during development. Notch is also necessary for appropriate development of the retina. Maintained expression of Notch causes the progenitor cells to develop as Müller glia (Vetter and Moore, 2001), like the support cells in the ear, GW-572016 ic50 and loss Notch effectors, Hes5, Hes1, and Hesr2 leads to a

reduction in Müller glial production (Hojo et al., 2000). Inhibition of the Notch pathway in the developing retina causes premature neural differentiation of the progenitor cells and the loss of Müller glia (Nelson et al., 2007). Although Notch is perhaps the best-studied signaling system in the sensory BAY 73-4506 cell line epithelia, several members of the FGF family of receptor tyrosine kinase ligands also are of critical importance. In the auditory epithelium of the inner ear, FGF20 and Fgfr1 are critical for the early stages of cochlear development, including the initiation of Atoh1 expression (Hayashi et al., 2008b and Pirvola

et al., 2002). Later in cochlear development, FGF8 and Fgfr3 are necessary for the proper differentiation of one type of supporting cell, the pillar cells (Colvin et al., 1996, Domínguez-Frutos et al., 2009, Hayashi et al., 2007, Jacques et al., 2007 and Puligilla et al., 2007). In the retina and olfactory system, FGF8 is also important for the early specification of the sensory domains, and several other FGFs and FGF receptors are expressed in these organs. Other signaling molecules, Carnitine dehydrogenase including members of the Wnt, BMP, EGF, and IGF families, have been shown to be involved in the normal development in these systems, and although the details may be different, there are many conserved features. Of the specialized sensory epithelia, the olfactory epithelium shows the most robust regeneration in response to injury (Graziadei and Monti Graziadei, 1985). All cell types, including the sensory receptor neurons, can be regenerated in all species that have been examined. Severing the axons at the lamina cribosa in rats and mice causes extensive apoptosis in the olfactory receptor neurons within a few days (Cowan and Roskams, 2002). The epithelium at this point contains only the sustentacular cells and the globose and horizontal basal cells.