583), VIQ (F = .520, P = .670), and PIQ (F = 1.184, P http://www.selleckchem.com/products/INCB18424.html = .321) among subgroups.3.2. Immediate Postoperative FollowupPostoperatively, IQ (P = .024) and PIQ (P = .004) of the extracerebral subgroup declined significantly, as indicated by Classification I. Nevertheless, the results of Classification III showed that VIQ (P = .009) of the right intracerebral subgroup improved significantly, which was not observed in the left intracerebral one (Figure 4).Figure 4Significant decline of the IQ (P = .024) and PIQ (P = .004) was found in the extracerebral subgroup after surgery, and the VIQ of the right intracerebral subgroup significantly improved (P = .009).3.3. Partial CorrelationAs indicated by partial correlation analysis, IQ showed a negative correlation with age, but a positive one with the years of education (Figures (Figures55 and and6).

6). Figure 5Partial correlation analysis showed a negative relation between age and IQ. Correlation coefficient was ?0.287 (P = .008).Figure 6Partial correlation analysis showed a positive relation between years of education and IQ. Correlation coefficient was 0.448 (P = .000).The tumor size was found to be negatively correlated with IQ, VIQ, and PIQ, respectively, exclusively in the intracerebral subgroup (Figures (Figures7,7, ,8,8, and and99).Figure 7Partial correlation analysis showed a negative relation between tumor size and IQ in the intracerebral subgroup. Correlation coefficient was ?0.383 (P = .005).Figure 8Partial correlation analysis showed a negative relation between tumor size and VIQ in the intracerebral subgroup.

Correlation coefficient was ?0.280 (P = .047).Figure 9Partial correlation analysis showed negative relation between tumor size and PIQ in the intracerebral tumor subgroup. Correlation coefficient was ?0.432 (P = .002).3.4. Three-Month FollowupThe full assessments of the 14 subjects, obtained at the followup of three months, indicated an improved VIQ (P = .001) when compared with that prior to their surgeries (Figure 10). Figure 10Improved VIQ (P = .001) was found in 14 patients three months after surgery.4. Discussions4.1. Tumor Malignancy, Location, and LateralizationMany cognitive investigations have dealt with low grade glioma, because patients with glioma live relatively a long survival life after surgery and adjuvant therapy, with an agreement on the negative effects on their cognition [1, 11�C13].

Patients with high-grade neoplasms have been proved to do more poorly in the neuropsychological test than those with low-grade tumors [14]. Scheibel’s Anacetrapib research, however, showed that malignancy grade exerted no effect on intelligence [15]. The current study proved that intelligence deficits occurred in patients with brain tumor, but did not show that tumor malignancy correlated with intelligence deficits. As indicated, no siginificant difference was found in IQ, VIQ, and PIQ between the patients with benign tumors and those with malignant ones before the operation.