40 Sleep fragmentation, characterized by an increase in the number of nocturnal awakenings

and time awake after sleep onset, is also a common sleep disturbance in patients with dementia of the type Protein Tyrosine Kinase inhibitor associated with Alzheimer’s disease.41 In Alzheimer dementia patients living in a residential care unit, it has been found that every hour of the night sleep was disturbed by wakefulness episodes and that every hour of daytime wakefulness was characterized by microsleeps.42 Also, sleep maintenance problems, secondary to psychiatric or medical disorders, Inhibitors,research,lifescience,medical may be more pronounced in elderly patients. This is mainly due to more fragmented sleep related to decreases in arousal threshold and sleep maintenance drive. Cyclic alternating pattern Another sleep microstructure phenomenon is the cyclic alternating pattern (CAP).3 CAP is a periodic EEG activity of NREM

Inhibitors,research,lifescience,medical sleep, characterized by sequences of transient electrocortical events that are distinct from background EEG activity and recur at quite regular intervals. CAP is mainly composed of phase A (activation) and phase B (the quiet interval until the next phase A), and it is a sign of sleep instability often accompanied by sleep stage changes or awakenings.3 The appearance Inhibitors,research,lifescience,medical of CAP sequences reflects arousal instability in a higher duration range than individual microarousals. In normal sleepers, CAP rate (percentage of CAP time in NREM sleep time) Inhibitors,research,lifescience,medical varies according to a U-shaped, age-related curve; the lower values are found in young adults, while the highest values are seen in elderly sleepers.43 CAP appears spontaneously, but also in association with identifiable sleep pathologies; its rate significantly increases in patients suffering from insomnia. In a study comparing a large

number of untreated depressed patients with an age-matched, gender-balanced, Inhibitors,research,lifescience,medical controlled group,44 no major difference was found in terms of sleep efficiency (above 95% in both groups) or any other sleep macrostructure index. However, a significant increase in unstable sleep was found in depressed patients, as reflected by the rate of CAP (60% in patients and 35% in normal subjects). This case underlines the value of microstructural scoring performed in addition to the usual sleep evaluation via macrostructural Phosphoprotein phosphatase analysis. EEG patterns It is often discussed whether slow phasic EEG activities, such as K-complexes and delta bursts, can be considered as arousals, since they often are associated with clear activation signs: heart rate acceleration, vasoconstriction, change in ventilation, and motor activation.45,46 The same question may apply to another phasic EEG activity, which is not necessarily clearly associated with activation signs, called sleep spindles. Sleep spindles and K-complexes constitute EEG markers of NREM sleep and particularly stage 2 sleep. Sleep spindles were first described by Hans Berger in 1933,47 but named by Loomis et al in 1935.