After the initial examination, a personal kit containing a new to

After the initial examination, a personal kit containing a new toothbrush (Leader?, Facilit Odontol��gica e Perfumaria Ltda., Rio de Janeiro, RJ, Brazil), and a test KRX-0401 or control gel was given to all participants. They were then instructed to apply the gel over all bristles of the toothbrush and brush their teeth for one minute, three times a day, using their habitual technique. Verbal and written instructions about the correct use of oral hygiene products were given to all subjects as well. In addition to verbal instructions, participants were given recommendations to follow at home. On the last day of the experiment stage (day 90), indices were recorded and the teeth were polished with pumice. Statistical analysis ANOVA and Student Newman-Keuls post-hoc analysis were performed to evaluate statistical differences between the control and test groups on days 0 and 90 (��=.

05). In each group, the mean scores of all indices were compared between baseline and the end of the trial with the paired t-test (��=.05). However, for illustrative purposes, the results are presented as means and standard deviations. RESULTS All participants completed the trial. Both test gels had good acceptance and did not produce any adverse effects, such as ulcerations or allergic reactions. At baseline, there was no statistically significant difference between the control and test groups with respect to mean PI (P=.8376) and BI (P=.3198). These findings indicated that all groups were well balanced at baseline (Tables 1 and and2).2). At day 90, there was a statistically significant difference in PI and BI scores between the control and test groups (P<.

05) (Table 1). Table 1 Plaque index (PI) on day 0 and day 90, control and test groups (mean + standard deviation). Table 2 Bleeding index (BI) on day 0 and day 90, control and test groups (mean �� standard deviation). Comparison of means between baseline and day 90 in each group showed a statistically significant difference in BI and PI scores for the CLX and LS groups in relation to the control group (P<.05), but no difference between the CLX and LS groups (P>.05) (Tables 1 and and22). DISCUSSION The inability of the adult population to perform adequate mechanical tooth cleaning has stimulated the search for chemotherapeutic agents that can improve plaque control and gingivitis.

4,5,6,7 This paper presents the data of a clinical study where a phytopharmaceutical agent in gel dentifrice formulation was used in a group of patients with gingivitis and compared GSK-3 with chlorhexidine digluconate. The design was based on previous studies and it was chosen to generate the best possible clinical evidence.14,25 Chlorhexidine digluconate has been tested for many years and its long-term efficacy and safety have been confirmed in several in vivo studies.

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