Argentina, Brazil and Mexico purchased vaccine to cover, on average, 44% of their populations. Countries that procured vaccine exclusively from the RF covered approximately 5% of their total population. Recipient countries of WHO donated vaccine were able to cover approximately 13% of their respective populations (Fig. 1). LAC countries established specific Alisertib vaccination goals for high risk groups, targeting approximately 147 million people. As of December 2010, an estimated 145 million doses had

been administered in LAC, representing approximately a 99% completion of the pre-established goal. Despite this high regional coverage, large variations by country in vaccination coverage of high risk groups existed (Table 1). Reported coverage of pre-established MDV3100 purchase target populations in LAC ranged from 1% to greater

than 100%. Fourteen countries and one territory (Montserrat) achieved target population coverage of ≥70%. Argentina, Brazil, Colombia, Cuba, Ecuador, El Salvador, Guatemala and Mexico reached ≥95% of their target populations. Not all countries reported disaggregated vaccine coverage data of individual prioritized risk groups. The highest coverage reported was for targeted individuals with chronic medical conditions, at an average of 110%, followed by health personnel and essential services, averaging 100% coverage. The lowest vaccination coverage was reported for pregnant women, averaging 67% of the pre-established goal. For other risk groups, 17 countries reported coverage ranging from 5% to greater than 100% (Table 1). Many LAC countries encountered difficulties vaccinating pregnant women, despite their high risk of influenza (H1N1) morbidity and mortality, especially in the 2nd and 3rd trimester of pregnancy, and in the first two weeks post partum [8] and [29]. Most LAC countries have developed ESAVI surveillance systems as part of their monitoring of regular vaccination activities. With pandemic influenza vaccination, special focus was given to clinical events such as Guillain-Barré Syndrome (GBS) and anaphylaxis [25]; updated alerts on vaccine safety were also sent periodically to countries to increase awareness of other possible ESAVI [30] and [31].

As of December 2010, the types of ESAVI following pandemic (H1N1) vaccination in LAC were similar to what would be expected with the seasonal influenza vaccine [10] and no deaths Bumetanide were identified as being causally related to the vaccine. The data presented are still preliminary, as countries’ are finalizing the classification of cases. A total of 13,621 ESAVI cases were reported to PAHO, 846 (6.2%) of them were classified by countries as severe (rate of 5.9 severe ESAVI per million doses administered). Of these, 389 cases were classified by countries as being related to vaccination itself (rate of 2.7 ESAVI per million doses administered) and 60 ESAVI were defined as programmatic errors (errors in vaccine storage, preparation, handling or administration) [32].