Biomaterials produced from artificial or natural polymeric hydrogels have discovered widespread applications in bio-medical engineering, ranging from tissue fix, regenerative medicine, to drug delivery. These benefits make supramolecular hydrogels a promising option for polymeric hydrogels. Conjugating enzyme inhibitor Among the molecules behave as the inspiration for supramolecular hydrogels, peptide based hydrogelators6 are common prospects because of their scientific relevance, more developed synthetic chemistry, and the capacity to create a large set of various molecules from a small variety of remains. There are lots of types of peptide based functional blocks in making nanofibers and generating hydrogels. The nano-fibers of peptide amphiphile compounds may present a top density of epitopes for regulating the difference of neuron progenitor cells or guiding cartilage regeneration. Home contrasting oligopeptides form the hydrogels for cell culture and cytokine release. 11 Amino-acid functionalized hydrogel particles release protein when triggered enzymatically. A modest peptide to conjugate with T lactam turns into a hydrogelator from the catalysis of a T lactamase. A low molecular-weight gelator containing amino-acid moieties Skin infection confers liquidcrystalline gels. Photo-sensitive spiropyran connecting with dipeptide contributes to supramolecular hydrogel to answer both light and ligand receptor interaction. It is essential and important to explore new ways for creating supramolecular hydrogels as intelligent materials for controlled Icotinib drug release in the particular sites or organs in a biological system. Because colonic micro-flora produces azo reductase to cut back the azo group in to the corresponding amine, olsalazine, being a prodrug and a substrate of azo reductase, defines colon specific drug-delivery via catalytic era of mesalazine inside the colon at the site of inflammation. Encouraged by these effects, we designed an olsalazine containing supramolecular hydrogel as a candidate of wise biomaterials for the controlled release. Specifically, we synthesized a hydrogelator using a tripeptide by-product that consists of a naphthyl group, two phenylalanines and one revised lysine deposit carrying an olsalazine moiety in the side chain. Home assembles to make a hydrogel at slightly acidic conditions. The reduction of olsalazine not only leads to gel to sol phase transition, but additionally produces 5 aminosalicylic acid.