Blood and breath samples were collected at baseline and at 30, 60 and 120 min after ingestion of 100 mg 13C-labeled glucose and 75 g glucose. Results: There SCH772984 cell line was a strong correlation between the change in the concentrations
at 2 h for the measured 13C-glucose breath test (2h-BT) and the 2 h plasma glucose level (r = −0.60, P < 0.0001). In a receiver–operator curve analysis using the 2h-BT, the area under the curve was determined to be 0.88, with a sensitivity and specificity (cut-off value of 3.5‰) of 82% and 85%, respectively, for the detection of DM. Multivariate analysis showed the 2h-BT to be an independent parameter to identify DM. Conclusion: The 13C-glucose breath test is a useful tool and has the potential to become a routine outpatient examination for the screening of DM in cirrhotic patients. "
“Recently, the beneficial
effects of increased physical activity (PA) on non-alcoholic fatty liver disease (NAFLD) in obese subjects have been reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective GSK2126458 nmr study was to estimate the beneficial effects of a varying volume of moderate- to vigorous-intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary MCE公司 restriction plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk-1, 42 performed MVPA for 150-250 min·wk-1, and 87 performed MVPA for >250 min·wk-1. The subjects in the MVPA ≥250
min·wk-1 group, in comparison with those in the MVPA <250 min·wk-1 group, showed significantly attenuated levels of hepatic steatosis (-31.8% vs. -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk-1 in comparison with that for <150 min·wk-1 led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% vs. -12.9%), levels of ferritin (-13.6% vs. +1.5%), and lipid peroxidation (-15.1% vs. -2.8%), and a significant increase in the adiponectin levels (+17.1% vs. +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and Carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusions: MVPA for ≥250 min·wk-1 as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (Hepatology 2014) "
“Autoimmune pancreatitis (AIP) is a distinct form of pancreatitis, which has a typical histopathology and excellent response to corticosteroids. AIP is sub-classified into Type 1 and 2 forms.