Conclusions: SWE and HRI measurements are non-invasive methods that can assist in clinical decision making in the assessment of fibrosis and steatosis in both OLT and non-OLT patients although caution should be exercised over the interpretation of these measurements in patients with a BMI>40. Disclosures: this website Edward I. Bluth – Advisory Committees or Review Panels: PHILLIPS; Grant/ Research Support: PHILLIPS The following people have nothing to disclose: George Therapondos, Michael T. Perry, Neal Savjani, Adriana Dornelles Background: Psoriasis is a chronic inflammatory immune-mediated skin disease which is showed to be associated with metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation
of metabolic syndrome, can progress to advanced fibrosis and cirrhosis. Liver biopsy is a gold standard method for assessing liver fibrosis; however it is invasive with possible risks. Liver stiffness measurement (LSM) by transient elastography (TE), a noninvasive liver fibrosis assessment tool, was evaluated in chronic liver diseases. We aimed to investigate the prevalence of significant liver fibrosis by LSM criteria and to identify the associate
factors of significant fibrosis in psoriatic patients. Rapamycin chemical structure Methods: A cross-sectional study was conducted at psoriasis clinic from January 2013 to December 2013. Psoriatic patients were invited to participate with the study. The subjects underwent laboratory tests for biochemistry, ultrasonography and TE (Fibroscan®) after overnight fasting. LSM ≥7.1 kPa was defined as a significant liver fibrosis. The prevalence of significant fibrosis was calculated. Univariate analysis was performed to identify factors associated with significant fibrosis. Factors with p-value less than 0.10 were analyzed with multivariate logistic regression analysis. A p-value <0.05 was taken as statistical significance. Results: One hundred and sixty-eight patients Isoconazole were enrolled. TE could not be performed in 3 patients due to obesity. Mean age was 49.22 (14.0) years. Ninety (54.5%) patients were female. Mean body mass index was 24.76 (4.7) kg/m2. Eighty-eight
(53.3%), 55 (33.3%) and 31 (18.8%) patients had hypertension, dyslipidemia and diabetes mellitus (DM). According to AHA/NHLBI criteria, metabolic syndrome was documented in 83 (50.3%) patients. Median duration of psoriasis was 13.00 (range: 0.4-68.0) years. Taking methotrexate over 1500 g in accumulating dosage was found in 39 (23.6%) patients. Mean LSM was 5.26 (2.9) kPa, and 18 (10.95%) patients had significant fibrosis. By multivariate analysis, DM (OR 17.65, 95%CI: 21.997-55.966; p=0.01), waist circumference (OR 1.24, 95%CI: 1.044-1.475; p=0.014) and AST level (OR 1.16, 95%CI: 1.052-1.288; p=0.003) were independently associated with significant fibrosis. Conclusions: Approximately 11% of psoriatic patients have significant liver fibrosis defined by transient elastography criteria.