High responsivity and specific detectivity values, at
a working bias of -2 V, were measured: 0.41 A/W and 8.6 x 10(11) cm Hz(1/2)/W for the In(0.14)Ga(0.86)As sub-detectors (at 980 nm), and 0.30 A/W and 2.0 x 10(14) cm Hz(1/2)/W for the In0.61Ga0.39P sub-detectors (at 680 nm). The successful integration of high-quality lattice-mismatched materials, combined with the excellent sub-detector performances, Alisertib chemical structure demonstrate the potential for extending such a multi-band photodetector technology to achieve simultaneous detection of a wide range of wavelength bands with tunable cut-off wavelengths. (C) 2011 American Institute of Physics. [doi:10.1063/1.3642981]“
“Purpose: Propolis, a product of honeybees, has anti-tumoural, cytotoxic, anti-metastatic and anti-inflammatory properties. The aim of this study was the evaluation of the radiosensitising capacity of Propolis in human head and neck squamous cell carcinoma (HNSCC) cells.
Materials and
methods: HNSCC cell lines (FaDu, UT-SCC15, UT-SCC45), fibroblasts (HSF2) and keratinocytes (HaCaT) were treated with Propolis (0-250 mu g/ml; 1, 4, 24 h) without and in combination with X-rays (0-6 Gy, single dose). Clonogenic survival, Blasticidin S in vivo proliferation, apoptosis, expression and phosphorylation of different signalling proteins were determined. Liquid chromatography-mass spectrometry (LC-MS) was performed on Propolis.
Results: Propolis significantly (P < 0.01) reduced cell growth and clonogenic survival in a time-and concentration-dependent manner. Propolis-induced apoptosis and Caspase 3 cleavage, increased phosphorylation of Extracellular signal Regulated Kinase 1/2 (ERK1/2), protein kinase Emricasan manufacturer B/Akt1 (Akt1) and Focal adhesion kinase (FAK). While a 1-h Propolis pretreatment was ineffective, a 3-h pretreatment significantly (P < 0.05) radiosensitised FaDu cells. LC-MS analysis identified 14 compounds of Propolis.
Conclusions: Our data show that Propolis exerts
cytotoxicity in a concentration-and time-dependent manner. In one out of three HNSCC cell lines, Propolis also caused an enhancement of radiosensitivity. Future studies on Propolis will shed further light on its potential as an adjuvant to radiotherapy.”
“Seizures are often the first manifestation of central nervous system dysfunction and are common in many inborn errors of metabolism, especially in neonates, infants, and children. A high index of suspicion is required to diagnose inborn errors of metabolism as the cause of seizures. It is also important to recognize these metabolic disorders early, as specific disease-modifying treatments are available for some with favorable long-term outcomes. This review discusses the classification of metabolic disorders as a cause of seizures based on pathogenesis and age and proposes a tiered approach for cost-effective diagnosis of metabolic disorders.