Isolated

spikes could also be observed in some animals after administration of (S)3,4-DCPG alone. The neuroprotective effect of (S)-3,4-DCPG was evaluated after 24 It and 6 days of survival www.selleckchem.com/products/th-302.html following DL-HCA-induced seizures. Massive neuronal degeneration was observed in a number of brain regions following infusion of DL-HCA alone (seizure group), whereas pretreatment with (S)-3,4-DCPG provided substantial neuroprotection. The present findings suggest that receptor subtype 8 of group III mGluRs may be considered a promising target for drug therapy in childhood epilepsies in the future. (C) 2007 Elsevier Ltd. All rights reserved.”
“Objectives: Despite pacemaker therapy in children and adolescents favoring an initial epicardial approach, predictors of lead failure have not been well clarified. The aim of this study was to assess the long-term outcomes and to determine predictors affecting lead durability in pediatric pacing therapy.

Methods: We reviewed the outcomes of 109 consecutive pacing leads implanted in 55 patients (median age, 5.2 years; range, 31 days -15.8 years), including 38 atrial and 71 ventricular leads. They consisted of 58 (53%) fishhooks, 37 (34%) screw-in leads, and 14 (13%) steroid-eluting suture-on leads. Seventy (64%) were implanted in patients with structural heart disease.

Results: The leads were followed for a median of 6.4 years (range, 3 days -22.9 years). Lead

failure occurred in 29 leads (27%; median of 8.4 years after implantation). Exit block or elevation of pacing threshold was the most common cause (n = 18), but CFTRinh-172 mw failures did not directly cause patient death. The overall 1-, 5-, 10-, and 15-year lead survivals were 100%, 89.0%, 72.5%, and 55.5%, respectively. Multivariate

Cox analysis revealed concurrent structural heart disease (relative risk, 2.85; 95% confidence interval, 1.27 -6.42; P =.011) to be the only significant predictor of lead failure.

Conclusions: Epicardial leads provide a reliable technique for managing rhythmic disturbance problems in the pediatric population. The only significant predictor of lead failure is the presence of structural heart disease.”
“The Arachidonate 15-lipoxygenase effects of S 24795, a newly developed partial agonist at alpha 7 nAChRs, were tested on synaptic transmission and plasticity using extracellular field excitatory postsynaptic potentials (fEPSPs) evoked in the CA1 region by Schaffer collateral stimulation in hippocampal slices obtained from adult mice. S 24795 reduced the amplitude of the fEPSPs in a concentration-dependent manner with an IC50 of 127 mu M and a Hill coefficient of 1.1. The reduction in amplitude of the fEPSPs started at S 24795 concentrations higher than 3 mu M and reached 71% of controls at 300 mu M. This effect was mediated by alpha 7 nAChRs since it was blocked by nAChR antagonists and was not observed in alpha 7-/- mice.