Many factors were found to affect the amount of alkaloids extracted: which parts of the plant were used roots gave
the highest yield; particle size of the material highest yield when the plant was sieved through size 40?mesh; the type of solvent a mixture of 0.1% hydrochloric acid with industrial alcohol was the best; The ratio of material to solvent 1 part plant material to eight parts solvent gave the highest extraction; the duration of the extraction 72?h and the number of re-extractions three also improved yield. The ratio of material to solvent had the most important impact on extraction efficiency while the number of re-extractions had a minor effect. The pesticidal activity of extracts was enhanced using this optimised technique.”
“The purpose of the study was to develop an optimized thermoreversible in situ Immunology & Inflammation inhibitor gelling IPI-145 molecular weight ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug.
A 3(2) full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 33-36 degrees C. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.”
“Two regioisomeric meroterpenoids, Eugenial A and B, have been isolated from the fruits of Eugenia LB-100 Others inhibitor multiflora and their structures established on the basis of NMR evidences. They possess
a phloroglucinol-monoterpene structure similar to the euglobals occurring in the sister genus Eucaliptus. A simple method to distinguish between regioisomeric pairs was pointed.”
“In the present study, antioxidant activity of methanolic extracts of the leaves of seven Egyptian Cassia species was investigated using two methods, the phosphomolybdate method and 1,1 diphenyl-2-picrylhydrazyl radical (DPPH.) scavenging activity method. The results revealed that C. glauca is the most potent species and that the activity of other plant species decreases in the following order: C. grandis > C. nodosa > C. fistula > C. didymobtrya > C. occidentalis > C. sophera.
Defatted methanolic extract of the most active plant C. glauca was subjected to fractionation using different organic solvents such as CHCl(3), EtOAc and BuOH.