Methods:
After obtaining the approval from animal investigation committee, 16 piglets were randomly assigned to circulatory arrest combined with either ASCP at 27 degrees C or DHCA at 18 degrees C for 90 min. Cerebral oxygen extraction fraction (COEF) from blood as well as cerebral tissue glucose, glycerol, lactate, pyruvate, and the lactate/pyruvate ratio (L/P ratio) by microdialysis were obtained selleckchem repeatedly.
Results:
COEF was lower during cooling and rewarming, respectively, in the DHCA18 group compared to the ASCP27 group (30 +/- 8
vs 56 +/- 13% and 35 +/- 6 vs 58 +/- 7%, respectively). Glucose decreased in both the DHCA18 and ASCP27 groups during the course of cardiopulmonary bypass (CPB), but were higher
in the ASCP27 group during ASCP, compared to the DHCA18 group during circulatory arrest (0.7 +/- 0.1 vs 0.2 +/- 0.1 mm center dot l(-1), P < 0.05). Pyruvate was higher (ASCP27 vs DHCA18: 53 +/- 17 vs 6 +/- 2 mu m center dot l(-1), P < 0.05), and the L/P ratio increased during circulatory arrest in the DHCA18 group, compared to the selective perfusion phase of the ASCP27 group (DHCA18 vs ASCP27: 1891 +/- 1020 vs 70 +/- 28, P < 0.01).
Conclusions:
In this piglet model, both cerebral oxygenation and microdialysis findings suggested a depletion of cerebral energy stores during circulatory arrest in the DHCA18 group, compared to selective cerebral perfusion combined with circulatory arrest in the ASCP27 group.”
“Objectives: To determine if the duration of wearing compression stockings after Napabucasin mw endovenous laser ablation (EVLA) of the great saphenous vein (GSV) has influence on pain and quality Stem Cell Compound Library of life.
Methods: This was a prospective randomized controlled trial. Between December 2006 and February
2008, 109 consecutive patients with EVLA of the GSV were analyzed. Deep vein insufficiency, ulceration, more than one insufficient vein in one leg, and use of anticoagulants were exclusion criteria. Group A used compression stocking for 48 hours after therapy, group B for 7 days. Pain (visual analogue scale [VAS]) and quality of life (SF-36) were analyzed 48 hours, 1 week, and 6 weeks after therapy. Three months after treatment, duplex ultrasound imaging was performed to assess occlusion rates.
Results: Both groups (group A, n = 37; group B, n = 32) where comparable at baseline. After 1 week, there was a significant difference in pain (VAS score 3.7 [+/- 2.1] vs. 2.0 [+/- 1.1], p <= .001), and physical dysfunction (group A, 85.1 [+/- 11.2] vs. group B, 95.7 [+/- 10.1]; p < .001) as well as vitality (group A, 75 [+/- 13.0] vs. group B, 83.7 [+/- 13.4]; p = .03), all in favor of group B, which disappeared after 6 weeks. After 6 weeks, no significant differences in all endpoints were present. Duplex ultrasound imaging revealed complete GSV occlusion in all patients, while no cases of deep venous thrombosis had developed.