On the basis of a WAXS
study, we showed that the linear derivatives are amorphous and that the interdigitation of alkyl chains between neighboring POSS molecules increases as the alkyl chain length increases from propyl to octyl. The thermal behavior of these compounds was studied by DSC, polarized optical microscopy and TGA in nitrogen and air atmosphere. The derivatives with shorter n-alkyl chains from C3 to C6 crystallize below 0 degrees C whereas the derivatives with longer n-alkyl chains (C7 and C8) can be regarded as amorphous glasses with a T(g) around -100 degrees C. The morphology and thermal properties change considerably with branching of the alkyl chain. Melting points above ambient temperature were found for the iso-hexyl and iso-heptyl POSS derivatives whereas the iso-pentyl POSS derivative is liquid at 25 degrees C. From the values of GNS-1480 in vitro the heat of fusion as well as entropy
of fusion, it was concluded that packing of the side groups in the crystal structure increases as the size of the branched alkyl group increases. TGA evidenced a negative effect of the branching of the alkyl chain on the thermal stability in air. (C) 2011 Elsevier Ltd. All rights reserved.”
“Accumulating evidence suggested that hyperglycemia played a critical role in hippocampus dysfunction in patients with diabetes mellitus. However, the multifactorial pathogenesis of hyperglycemia-induced impairments of hippocampal neurons has not been fully elucidated. Docosahexaenoic acid (DHA) has been shown to NCT-501 enhance learning and memory and affect neural function in various experimental
conditions. The present study investigated the effects of DHA on the lipid peroxidation, the level of inflammatory cytokines and neuron apoptosis in the hippocampal neurons in high-glucose condition. High-glucose administration increased the level of tumor necrosis factor a (TNF-alpha) and IL-6, induced oxidative Selleck Barasertib stress and apoptosis of hippocampal neurons in vitro. DHA treatment reduced oxidative stress and TNF-alpha expression, protected the hippocampal neurons by increasing AKT phosphorylation and decreasing caspase-3 and caspase-9 expression. These results suggested that high-glucose exposure induced injury of hippocampal neurons in vitro, and the principle mechanisms involved in the neuroprotective effect of DHA were its antioxidant and anti-apoptotic potential. DHA may thus be of use in preventing or treating neuron-degeneration resulting from hyperglycemia. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Macrocycles are ideal in efforts to tackle “difficult” targets, but our understanding of what makes them cell permeable and orally bioavailable is limited.