Stat3C mice in the two-stage skin tumor study. ACA and FA also demonstrated a promising suppression of tumorigenesis in the K5.Stat3C mice, something that ATRA was not able to do. This may be useful clinically in 17-AAG mw individuals that already exhibit activated Stat3. These results further support the idea that targeting multiple pathways (Stat3, NF-κB) will be an effective strategy for chemoprevention. Grant Support Grant from the Feist-Weiller Cancer Center, NU7441 the Department of Pharmacology, Toxicology & Neuroscience. This research was also supported, in part, by National Cancer Institute grants 1K22CA102005-01A2
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