There were no significant differences in the ratio of laparoscopic appendectomy, operating time, the ratio of complicated appendicitis, and the ratio of accompanying external drainage procedure, and the ratio of accompanied by appendicoliths. There were significant differences between two groups in the ratio of operation at night (Group A, LEE011 datasheet 22.0% and Group B, 5.1%; p < 0.0001), and in the ratio of accompanying external drainage procedure (Group A, 24.9% and Group B, 12.2%; p = 0.0033). Table 2 RAD001 datasheet Comparisons of demographics and preoperative characteristics between two groups Group A (≤ 8 hours) Group B (> 8
hours) P value Number of cases 177 (53.2%) 156 (46.8%) Age (yrs) 35.9 ± 125 34.7 ± 12.1 0.3758 Sex ratio (Male: Female) 103:74 87:69 0.6592 Body mass index (kg/m2) 23.1 ± 3.4 22.7 ± 3.1 0.2822 Body temperature (°C) 37.4 ± 0.7 37.4 ± 0.6 0.7701 Initial white blood cell count (×103/mm3) 12.6 ± 3.8 13.3 ± 4.0 0.1150 Comorbidities 21 (11.9%) 11 (7.0%) 0.1915 Hours from onset of symptoms to hospital 26.4 ± 22.5 22.0 ± 16.7 0.1835 Hours from arrival to diagnosis 2.4 ± 1.1 3.6 ± 2.6 <0.0001 Hours from diagnosis to operation 3.4 ± 1.4 10.4 ± 4.3 <0.0001 Hours from arrival to operation 5.8 ± 1.5 13.9 ± 4.0 <0.0001
Table 3 Comparisons of operative characteristics between two groups Group A (≤ 8 hours) Group B (> 8 hours) P value Laparoscopic appendectomy, case (%) 42 (23.7%) 43 (27.6%) 0.4513 Operation at night (22:00–06:00), case (%) 39 (22.0%) GDC-0449 8 (5.1%) <0.0001 Operating time (minute) 56.3 ± 21.8 53.5 ± 19.4 0.2236 Complicated appendicitis, case (%) 40 (22.6%) 28 (18.0%) 0.3408 Appendicoliths, case (%) 73 (41.2%) 55 (35.3%) 0.3097 Combined drainage, case (%) 44 (24.9%) 19 (12.2%) 0.0033 Comparisons of postoperative
outcomes between two groups are shown in Table 4. The mean WBC count at postoperative first day of group B were lower than that of group A (p = 0.0039). There were no significant differences in time to soft diet, length of postoperative Ribose-5-phosphate isomerase hospital stay, complication rate, and readmission rate between two groups. Although surgical site infection (SSI) rate including intra-abdominal abscess (IA) of group B was slightly higher than that of group A, there was also no significant statistical difference (Group A, 1.7% and Group B, 3.9%; p = 0.3143). Table 5 shows results of hospital costs between two groups and there were no significant differences in all comparative variables. Table 4 Comparisons of postoperative outcomes between two groups Group A (≤ 8 hours) Group B (> 8 hours) P value WBC, postoperative first day (×103/mm3) 10.5 ± 3.2 9.5 ± 3.3 0.0039 Time to soft diet (day) 1.9 ± 1.1 1.7 ± 0.8 0.0806 Postoperative hospital stay (day) 4.9 ± 2.8 4.4 ± 2.7 0.0719 Complication, case (%) 3 (1.7%) 8 (5.1%) 0.1225 Surgical site infection, case (%) 3 (1.7%) 6 (3.9%) 0.3143 Readmission within 30 days, case (%) 1 (0.6%) 1 (0.6%) 1.