There will be a group of seven Executive Editors representing a wide range Y 27632 of specialist interests and they will handle the review process for papers. The Editorial Board will be expanded enabling the review of a larger proportion of papers within the Board. Where good quality papers are judged to be unsuitable for publication in Neuropathology and Applied Neurobiology authors will be offered the option that these are forwarded, together with the reviews, to the Wiley open access journal Brain and Behavior. Our readers remain in the focus and for them we must provide

novel, insightful and relevant papers with a broad approach to neuropathology and neuroscience. Accessibility of published material is important and Neuropathology and Applied Neurobiology participates in the Wiley-Blackwell Open Access program, OnlineOpen. Wiley-Blackwell also makes Neuropathology and Applied Neurobiology available to institutions in a number of developing countries at reduced, or no cost, supporting scientists from all backgrounds. Our comprehensive review papers and, in particular, the annual review MI-503 edition, have proved extremely popular with readers and these will continue. A new

venture for the Journal is the appointment of a Social Media Editor and I welcome Dr Abi Li to this position. It is vital that we engage in new approaches to promote access and awareness of the Journal and its content Baricitinib to a global readership, we will be at the forefront of such developments. “
“M. Hasselblatt, B. Riesmeier,

B. Lechtape, A. Brentrup, W. Stummer, F. K. Albert, A. Sepehrnia, H. Ebel, J. Gerß and W. Paulus (2011) Neuropathology and Applied Neurobiology37, 803–806 BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults Aim: Duplication of 7q34 resulting in generation of BRAF-KIAA1549 fusion transcripts is a characteristic event in pilocytic astrocytoma that may also aid distinction from diffuse astrocytic tumours. As data on BRAF-KIAA1549 fusion transcript status remain mainly limited to children, we aimed to examine the diagnostic value of BRAF-KIAA1549 fusion transcripts across all age groups. Methods:BRAF-KIAA1549 fusion transcript status was examined using reverse transcription polymerase chain reaction on formalin-fixed paraffin-embedded samples of 105 primary pilocytic astrocytomas [median patient age: 17 years (1–74 years)]. Results: Informative results (distinct wildtype BRAF bands detectable) were obtained in 105/124 cases (85%). Fusion transcripts were detected in 53 of cases (51%). They were more often encountered in tumours of infratentorial location [42/67 (63%) vs. 11/38 (29%)] and comprised KIAA1549-Ex16_BRAF-Ex9 (32 cases), KIAA1549-Ex15_BRAF-Ex9 (14 cases) and KIAA1549-Ex16_BRAF-Ex11 (seven cases).