Volume and pressures were recorded at various sensations up to maximal capacity (MCC). Maximal capacity was considered a volume with strong feeling of fullness in lower CHIR99021 abdomen or filling pressure of 30 cmH2O, whichever was reached earlier. At the end of the filling phase, the patient was asked to void in the uroflowmeter. He was encouraged to void with pelvic-floor relaxation along with Crede’s maneuver/straining. The following definitions were used: (i) Pouch compliance = MCC/end.fill.Ppouch; (ii) MCC = voided volume + PVR. This definition was used rather

than “volume filled” to account for the urine production during the study; (iii) clinically significant incontinence = leakage of over a few drops of urine. Urethral pressure profilometry was performed after filling 100 mL infusate into the pouch. The catheter was pulled at a constant rate (2 mm/sec) using motor-driven automated catheter puller and urethral pressures were recorded. The above evaluation was conducted initially at least 6 weeks after surgery and later at least 3 months after the initial

evaluation. All patients were counseled and trained to void on schedule by sphincter relaxation along with Crede’s maneuver learn more if required. The pelvic floor strengthening exercises were started in the preoperative period and continued thereafter. Pelvic floor rehabilitation was initiated just before removal of catheter. Data were analyzed using statistical package for social science (SPSS, version 17, Chicago, IL, USA). Normality of data were checked using one sample Kolmogorov–Smirnov test. The before-and-after comparisons were made using paired t-test (parametric), Wilcoxon signed rank test (non-parametric) or McNemar test (dichotomous categorical).

Correlations between clinical/QOL and urodynamic parameters were made using Pearson’s correlation (parametric) or Spearman’s rank correlation (non-parametric). Factors predicting continence status were examined using Mann–Whitney U-test (non-parametric dataset). Binominal logistic regression and stepwise linear regression analyses were conducted as appropriate. Total 17 patients with mean age 52.7 ± 11.3 years and body mass index 22.7 ± 3.3 kg/m2 were evaluated. All patients underwent cystoprostatectomy (radical in 16 patients with Aprepitant bladder cancer and simple in one patient with genitourinary tuberculosis) and construction of orthotopic neobladder (ONB) with ileum of mean length 48 ± 7 cm (range 40–60 cm). Three patients of bladder cancer developed recurrence; one in corpus cavernosus of penis, one in the pelvis and one in both. All were treated with systemic chemotherapy and the latter two with pelvic radiotherapy in addition. The former patient had a complete remission of disease; the latter two succumbed to progressive disease and hence were excluded.