9, -0.5±1.4 %, p=0.35). There was a significant increase in 1RM for bench press in all groups over time (8.1±9.7 kg, p<0.01) with no differences between groups (KA-L 7.1±3; KA-H 7.3±15; CrM 10±8 kg, p=0.73). There was no significant change in leg press 1RM (p=0.33). Total work performed on the WAC test increased in all groups over time (-69±1,030, 552±1,361

J, p=0.003) with no differences among groups (KA-L -278±676, 64±1,287; KA-H 412±1,041, 842±1,369; CrM -301±1,224, 775±1,463 J, p=0.27). Conclusions Neither manufacturers recommended doses or equivalent loading doses of KA promoted CHIR98014 clinical trial greater changes in muscle creatine content, body composition, strength, or anaerobic capacity than CrM. These findings do not support claims that KA is a more efficacious form of creatine. Acknowledgements Supported by AlzChem AG, Germany.”
“Background Athletes exposed to extreme training loads such as those that occur during multiple-game tournaments, two a day practices, or sudden increases in volume are prone to overreaching. Beta-hydoxy-beta-methylbutyrate (HMB) is thought to increase regenerative capacity following high intensity exercise. However, to date, its effects on muscle damage, hormonal status, and AZD2171 cost performance during overreaching have yet to be investigated. Therefore the purpose of this investigation was to determine the effects of HMB free acid (HMB-FA) supplementation on indices of muscle damage, strength, Epigenetics inhibitor power, and cortisol

following a 2-week overreaching cycle. Methods Twenty resistance trained males aged 21.3 ± 1.9 years were recruited for the study and randomly assigned to consume 3 g per day of HMB-FA (combined with food-grade orange flavors and sweeteners) or a placebo (food-grade orange flavors and sweeteners). All subjects were placed on a diet consisting of 25 % protein, 50 % carbohydrates, and 25 % fat by a registered dietician who specialized in sport (RD, LDN, CISSN).

Seventy-two hours prior to the overreaching phase subjects were tested for baseline measures of creatine kinase (CK), cortisol, Wingate power and strength on the squat, bench press, and deadlift. Following, all subjects participated in a 2-week high volume resistance-training cycle. Each Monday through Thursday, subjects performed 3 maximal sets of 8-12 repetitions and 60-90 seconds rest of squats, leg press, bench press, deadlifts, pull-ups, military press, bent over rows, barbell O-methylated flavonoid curls and extensions. On Friday subjects were given three 1-RM attempts on the squat, bench press, and deadlift for a total of 9 maximal working sets, followed by power testing on the Wingate on Saturday. A 2 X 3 (Group X time (weeks 0, 1, and 2)) repeated measures ANOVA was used to assess any main effects. If main effects were found LSD post hoc tests were incorporated to determine where differences were located. Results Significant group X time effects were found for CK, which relative to baseline values (256.1 ± 28.3 U/L) increased at weeks 1 (493.8 ± 36.3 U/L) and 2 (533.4 ± 49.