MK801 (0.050.1 mg.kg-1, intraperitoneal [IP]) caused similar effects, but, with lesser changes in power. Figure 2. Dose-response effects of subcutaneous phencyclidine (PCP) 1 mg.kg-1 on electroencephalographic (EEG) spectral power in the prefrontal cortex and sensorimotor cortex in conscious rats. The abscissa represents the EEG spectral component between 1 and 30 … In contrast, the noncompetitive AMPA (amino-3hydroxy-5-methyl-4-isoxazole propionic acid) antagonists GYKI 52466 and GYKI 53655 Inhibitors,research,lifescience,medical increased RRG power over the whole power spectrum (1-10 mg.kg-1, IP). Clozapine, an atypical antipsychotic
agent (0.2 mg.kg-1, subcutaneous) synchronized the RRG (peak 8 Hz) (Figure 3.) The 5-HT2A antagonist M100907 specifically increased RRG Inhibitors,research,lifescience,medical power at 2 to 3 Hz at low doses (10 and 50 ug.kg-1 subcutaneous), whereas at higher doses (0.1 mg.kg-1, subcutaneous) the profile resembled that of clozapine. Figure 3. Dose-response effects of subcutaneous clozapine (0.2 mg.kg-1) expressed as percentage change of electroencephalographic (EEG) spectral power in the prefrontal cortex and sensorimotor cortex of conscious
rats at each frequency between 1 and 30 Hz. Vertical … Clozapine (0.2 mg.kg-1, subcutaneous), GYKI 53655 (5 mg.kg-1, IP), prazosin (0.05 and 0.1 mg.kg-1, IP), and M100907 (0.01 Inhibitors,research,lifescience,medical and 0.05 mg.kg-1, subcutaneous) antagonized the decrease in power between 5 and 30 Hz caused by PCP (1 mg.kg-1, subcutaneous), but not the increase in power at 1 to 3 Hz in prefrontal Inhibitors,research,lifescience,medical cortex (Figure 4.) Figure 4. Coadministration of subcutaneous phencyclidine (PCP) (1 mg.kg-1) and
clozapine (0.2 mg.kg-1), expressed as percentage change of electroencephalographic (EEG) spectral power in the prefrontal cortex and sensorimotor cortex of conscious rats at each frequency … Conclusion Thus, clozapine, supposedly the best antipsychotic agent, available, apart from its limiting side effects, clearly increased theta rhythm in prefrontal cortex, indicating beneficial effects on cognition. Clozapine also partially antagonized Inhibitors,research,lifescience,medical the effects of PCP on RRG, but only the desynchronization. These results clearly show that the effects next of PCP on RRG can be used a model for schizophrenia, which may be transposable to man. The profiles of compounds screened for activity in this model are allowing new selleck compound therapies for schizophrenia to be developed, particularly if all the effects of PCP may be antagonized.
Animal models are defined as experimental preparations developed in one species in order to study phenomena existing in another species. When addressing animal models of human psych opathology, attempts are made to reproduce in animals some syndromes or symptoms resembling as far as possible some human syndromes or symptoms in order to study particular aspects of human psychopathology.